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Treatment > Chemotherapy
Sunitinib SU011248
Index
- Basic Description
- Trials
- Other Known Uses
- Special Precautions
- Side Effects - Minor
- Side Effects - Serious - Contact Doctor
Basic Description:
Sunitinib SU011248
"Sunitinib marketed as Sutent by Pfizer, and previously known as SU11248) is an oral, small molecule, multi targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sunitinib was the first cancer drug simultaneously approved for two different indications." - Wikipedia |
Trials:
- Sunitinib in Treating Patients With Recurrent or Unresectable Meningioma, Intracranial Hemangiopericytoma, or Intracranial Hemangioblastoma - www.ClinicalTrials.gov
- Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma - www.ClinicalTrials.gov
Other Known Uses:
- treat gastrointestinal stromal tumors (GIST; a type of tumor that grows in the stomach, intestine (bowel), or esophagus (tube that connects the throat with the stomach) in people with tumors that were not treated successfully with imatinib (Gleevec) or people who cannot take imatinib.
- to treat advanced renal cell carcinoma (RCC, a type of cancer that begins in the cells of the kidneys).
Special Precautions:
- Tell your doctor and pharmacist if you are allergic to sunitinib, mannitol, or any other medications.
- Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take
- Tell your doctor and pharmacist what herbal products you are taking, especially St. John's wort. Your doctor will probably tell you not to take St. John's Wort while taking sunitinib.
- Tell your doctor if you have or have ever had a bleeding problem; angina (chest pain); a slow, fast, or irregular heartbeat; a heart attack; heart bypass surgery; heart failure; high blood pressure; pulmonary embolism (PE; blood clot in the lungs); seizures; a stroke or transient ischemic attack (TIA, mini-stroke); or heart, kidney, liver, or thyroid disease.
- Tell your doctor if you are pregnant, could be pregnant, or plan to become pregnant. You should not become pregnant while you are taking sunitinib.
- Tell your doctor if you are breast-feeding. You should not breast-feed while you are taking sunitinib.
- If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking sunitinib.
- Sunitinib may cause your skin to turn yellow and your hair to lighten and lose color. This is probably caused by the yellow color of the medication and is not harmful or painful. Your natural skin and hair color will likely return after you stop taking sunitinib.
- Sunitinib may cause high blood pressure. Your blood pressure should be checked regularly while you are taking sunitinib.
- Do not eat grapefruit or drink grapefruit juice while taking this medication.
Additional Side Effects - Minor:
- Change In The Way Things Taste
- Constipation
- Depression
- Diarrhea
- Dry Mouth, Pain, Irritation, or Burning Sensation of The Lips, Tongue, Mouth or Throat
- Dryness, Thickness, Cracking, Or Blistering Of Skin On The Palms Of The Hands And The Soles Of The Feet
- Extreme Tiredness
- Gas
- Hair Loss
- Heartburn
- Loss Of Appetite
- Muscle Or Limb Pain
- Nausea
- Pain, Burning, Numbness, Or Tingling In The Hands Or Feet
- Rash
- Slow Speech
- Thin, Brittle Fingernails Or Hair
- Unusual Discomfort In Cold Temperatures
- Vomiting
- Weakness
- Weight Loss
- White Patches, Sores On The Lips, or In The Mouth And Throat
Side Effects - Immediately Contact Doctor:
Major side effects are uncommon. Since people with NF2 are taking these medications at a low dose, only minimal side effects are common. However, long term use is primarily where these major side effects take place. Monthly Blood and Urine Tests can usually point to an issue before it's a real problem. Talk to your doctor.
- Black And Tarry Stools
- Bloody Vomit
- Chest Pain
- Chills
- Coughing Up Pink Or Bloody Mucus
- Difficulty Falling Asleep Or Staying Asleep
- Fever
- Increased Urination, Especially At Night
- Rapid, Irregular, Or Pounding Heartbeat
- Red Blood In Stools
- Shortness Of Breath
- Stomach Pain Or Swelling
- Sudden Severe Back, Stomach, Or Leg Pain
- Swelling Of The Feet Or Ankles
- Swelling, Tenderness, Warmth, Or Redness Of A Leg
- Unusual Bruising Or Bleeding
- Vomit That Looks Like Coffee Grounds
- Weight Gain