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NF2 Tumor Suppressor List
Last Updated: March 20th, 2012
Index
- Table 1 - Top NF2 - Chemotherapy & Other Pharmaceutical Tumor Suppressors
- Table 2 - Additional NF2 - Chemotherapy & Other Pharmaceutical Tumor Suppressors
- Table 3 - NF2 Botanicals / Natural Compounds
- Table 4 - Source and Dose
- Definitions
- NF2 Clinical Trial Listing
Table 1 - Chemotherapy Tumor Suppressor List
Table 2 - Addional Chemotherapy Tumor Suppressor List
Table 3 - National Compounds / Supplements / Botanical
Table 4 - Source and Dose
- The dose to take is based on weight, the suggestion is 1ml for each 22lbs of your weight. So 5ml per day if your weight is 110lbs.
- Also, ideally this should dose should be separated to be taken during the course of the day.
- Since Propolis does not have a pleasant taste, it helps to first fill the liquid in size 00 size capsules.
Definitions
- Angiogenesis Inhibitor
- Anti-inflammatory
- Apoptosis
- Ataluren
- Bioavailability
- Botanical
- CAPE (Caffeic Acid Phenethyl Ester)
- Curcuminoid
- EGFR (Epidermal Growth Factor Receptor)
- HDI Inhibitor, HDAC (Histone Deacetylase Inhibitors)
- HER2/neu (Human Epidermal growth factor Receptor 2)
- INN, or rINN
- mTOR Inhibitor (mammalian target of rapamycin)
- Necrosis
- Orphan Drug
- PI3K Inhibitor (Phosphoinositide 3kinase Inhibitor)
- RNR Inhibitor (Ribonucleotide Reductase Inhibitor)
- Somatostatin (Somatostatin Receptor Type 5)
- TKI Inhibitor (Tyrosine Kinase Inhibitor)
- Angiogenesis Inhibitor
- Anti-inflammatory
- Apoptosis
- Ataluren
- Bioavailability
- Botanical
- CAPE (Caffeic Acid Phenethyl Ester)
- Curcuminoid
- EGFR (Epidermal Growth Factor Receptor)
- HDI Inhibitor, HDAC (Histone Deacetylase Inhibitors)
- HER2/neu (Human Epidermal growth factor Receptor 2)
- INN, or rINN
- mTOR Inhibitor (mammalian target of rapamycin)
- Necrosis
- Orphan Drug
- PI3K Inhibitor (Phosphoinositide 3kinase Inhibitor)
- RNR Inhibitor (Ribonucleotide Reductase Inhibitor)
- Somatostatin (Somatostatin Receptor Type 5)
- TKI Inhibitor (Tyrosine Kinase Inhibitor)
NF2 Clinical Trial Listing
| Med ID | Mechanism of Action | INN / US Name | Link | |
|---|---|---|---|---|
| 1 | mTOR Inhibitor | Everolimus, RAD-001 | Afinitor, Novartis | - More Info |
| 2 | Angiogenesis Inhibitor | Bevacizumab, Avastin | Genentech,Roche, Genentech, OSI Pharmaceuticals | - More Info |
| 3 | TKI Inhibitor | Lapatinib | Tykerb, GlaxoSmithKline | - More Info |
| 4 | TKI Inhibitor | Erlotinib | Tarceva, Genentech USA | - More Info |
| 5 | TKI Inhibitor | Sunitinib, SU011248 | Sutent, Pfizer | - More Info |
| 6 | TKI Inhibitor | Imatinibn, Imatinibn Mesilate | Gleevec, Glivec, Novartis | - More Info |
| 7 | TKI Inhibitor | Sorafenib | Nexavar, Onyx Pharmaceuticals | - More Info |
| 8 | TKI Inhibitor | Nilotinib | Tasigna, Novartis | - More Info |
| 9 | Angiogenesis Inhibitor | PTC 299 | Roche, PTC Therapeutics | - More Info |
| 10 | Somatostatin | Pasireotide | SOM230, Novartis | - More Info |
| 11 | RNR Inhibitor | Hydroxycarbamide, Hydroxyurea | Hydrea, Droxia, Bristol-Myers Squibb | - More Info |
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| Med ID | Mechanism of Action | INN / US Name | Link | |
|---|---|---|---|---|
| 12 | mTOR Inhibitor | Sirolimus | Fermentek, Rapamune | - More Info |
| 13 | EGFR Inhibitor | Cetuximab, IMC-C225 | Erbitux, Bristol-Myers Squibb | - More Info |
| 14 | HER2/neu | Trastuzumab | Herceptin, Genentech | - More Info |
| 15 | TKI Inhibitor | Vandetanib | Zactima, AstraZeneca | - More Info |
| 16 | TKI Inhibitor | Dasatinib | SPRYCEL, Bristol-Myers Squibb | - More Info |
| 17 | TKI Inhibitor | Nintedanib, Intedanib, BIBF 1120 | Vargatef, Vargate, Boehringer Ingelheim | - More Info |
| 18 | PI3K Inhibitor | BEZ235 | NVP-BEZ235, Novartis | - More Info |
| 19 | Ataluren | PTC124, Ataluren | Roche, PTC Therapeutics | - More Info |
| 20 | HDI Inhibitor, HDAC | AR 42, OSU HDAC42 | Ohio State University, Arno Pharmaceutical | - More Info |
| 21 | PDK1 Inhibitor | AR 12, OSU 03012 | Ohio State University, Arno Pharmaceutical | - More Info |
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| Med ID | Name |
|---|---|
| 22 | Boswellia, 5 LOXIN, |
| Findings suggest Bowellia.s effectiveness in reducing cerebral edema (an excess accumulation of water in the intracellular or extracellular spaces of the brain) in patients with brain tumors following radiotherapy. Memorial SloanKettering Cancer Center - More Info | |
| 23 | BIO30, Propolis, |
| High in bioflavonoids proven to stop cancer tumours and provide powerful antibacterial, antimycotic, antiviral, antioxidant, and anti-inflammatory health protection. - More Info | |
| 24 | Bio-Curcumin, |
| Curcumin induces apoptosis in human colon cancer, promyelocytic leukemia cells, and inhibits growth of uterine leiomyosarcoma cells. Curcumin also potentiated gemcitabine action in both in vitro and in vivo studies of pancreatic cancer. In a phase II trial in pancreatic cancer patients, down-regulation of NF-kappa B and cyclooxygenase-2 were observed. Oral administration is well tolerated, but bioavailability is relatively low. Memorial SloanKettering Cancer Center - More Info | |
| 25 | Honocure, Honokiol, |
| Recent studies have explored honokiol and found validation for it as a treatment option for anxiety, cancer, peridontal disease, stroke, inflammation, and even weight loss.<br> Honokiol has been effective in vitro and in vivo against several types of cancers. It appears to turn off the division of some cancer cells while inducing others to kill themselves, apoptosis. - More Info | |
| 26 | Omega 3, |
| Bioavalability, loss of strength in nutrients due to the digestion process, makes it hard to actually get what you want from medication and supplements taken orally, for Resveratrol and Curcumin. The fatty acid in a supplement or foods that have Omega 3, makes it easier to actually absorb nutrients in other things taken orally. - More Info | |
| 27 | Resveratrol, |
| Resveratrol has antioxidant and anti-inflammatory properties as evidenced by its cardioprotective effects. It reduces the oxidation of low density lipoproteins (LDL) and inhibits aggregation of platelets and may offer protection against atherogenesis and has shown an increase in cerebral blood flow in healthy volunteers while performing cognitive tasks. Memorial SloanKettering Cancer Center - More Info | |
| 28 | Zyflamend, New Chapter |
| Inhibits COX-1 and COX-2 enzymes, induces apoptosis, and inhibits proliferation of human prostate cancer cells. Memorial SloanKettering Cancer Center - More Info | |
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| Name | Dose | Best Source/Brand to Buy |
|---|---|---|
| Propolis, Bio30 | See Below | http://www.manukahealth.co.nz |
| BioCurcumin | 400mg/Day | http://www.lef.org/Vitamins-Supplements/Item00407/Super-Bio-Curcumin.html |
| Zyflamend, New Chapter | http://www.newchapter.com/zyflamend/zyflamend | |
| Boswellia, 5Loxin | http://www.lef.org/Vitamins-Supplements/Item01639/5-LOX-Inhibitor-with-ApresFlex.html?source=search&key=Boswellia | |
| Resveratrol | 250mg/Day | http://www.lef.org/Vitamins-Supplements/Item01430/Optimized-Resveratrol-with-Synergistic-Grape-.html?source=search&key=RESVERATROL |
| Honocure, Honokiol | http://www.econugenics.com/p-126-honopure.aspx | |
| Omega 3 | Any |
Propolis
"An angiogenesis inhibitor is a substance that inhibits the growth of new blood vessels (angiogenesis). Some angiogenesis inhibitors are a normal part of the body's control, some are administered as drugs, and some come from diet. When solid cancers are small, they are supplied with nutrients by diffusion from nearby blood vessels. In order to grow larger, they need their own blood vessels, which they create by angiogenesis promoters such as VEGF. Drugs that interrupt that process show promise in treating cancer. However, when one angiogenesis promoter is blocked, cancers eventually grow blood vessels using another angiogenesis promoter." - Wikipedia
Return to Top"Anti-inflammatory refers to the property of a substance or treatment that reduces inflammation. Anti-inflammatory drugs make up about half of analgesics, remedying pain by reducing inflammation as opposed to opioids, which affect the central nervous system." - Wikipedia
Return to Top"Apoptosis is the process of programmed cell death (PCD) that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation. Unlike necrosis, apoptosis produces cell fragments called apoptotic bodies that phagocytic cells are able to engulf and quickly remove before the contents of the cell can spill out onto surrounding cells and cause damage. In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis, in general, confers advantages during an organism's life cycle." - Wikipedia
Return to Top"Ataluren is designed to allow the ribosome to ignore the premature stop signal and continue translation of the mRNA, resulting in formation of a functioning protein. Ataluren does not cause the ribosome to read through the normal stop signal. Ataluren has the potential to address the underlying cause of the disease by overriding the premature stop signal, enabling the synthesis of a functioning protein. Ataluren does not alter the patient's genetic code or introduce genetic materials into the body." - PTC Therapeutics
Return to Top"In pharmacology, bioavailability (BA) is a subcategory of absorption and is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. By definition, when a medication is administered intravenously, its bioavailability is 100%. However, when a medication is administered via other routes (such as orally), its bioavailability generally decreases (due to incomplete absorption and first-pass metabolism) or may vary from patient to patient. Bioavailability is one of the essential tools in pharmacokinetics, as bioavailability must be considered when calculating dosages for non-intravenous routes of administration. For dietary supplements, herbs and other nutrients in which the route of administration is nearly always oral, bioavailability generally designates simply the quantity or fraction of the ingested dose that is absorbed." - Wikipedia
Return to Top"A drug made from part of a plant, as from roots, leaves, bark, or berries." - Dictionary.com
Return to Top"CAPE blocks the formation of tumors by down-regulating the PAK gene. PAK is an enzyme essential for a number of physiological functions such as cell growth and migration, blood vessel function and memory/learning." - Bio30.com
Return to Top"A curcuminoid is a curcumin or a derivative of a curcumin with different chemical groups that have been formed to increase solubility of curcumins and make them suitable for drug formulation. These compounds are natural phenols and produce a pronounced yellow color. Many curcumin characters are unsuitable for use as drugs by themselves. They have poor solubility in water at acidic and physiological pH, and also hydrolyze rapidly in alkaline solutions. Therefore, curcumin derivatives are synthezised to increase their solubility and hence bioavailability." - Wikipedia
Return to Top"The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB 1), HER2/c neu (ErbB 2), Her 3 (ErbB 3) and Her 4 (ErbB 4). Mutations affecting EGFR expression or activity could result in cancer." - Wikipedia
Return to Top"Histone Deacetylase Inhibitors, are a class of compounds that interfere with the function of histone deacetylase. HDIs have a long history of use in psychiatry and neurology as mood stabilzers and anti-epileptics. More recently they are being investigated as possible treatments for cancers and inflammatory diseases." - Wikipedia
Return to Top"Human Epidermal growth factor Receptor 2, also known as proto-oncogene Neu, receptor tyrosine-protein kinase erbB-2, CD340 (cluster of differentiation 340) or p185 is an enzyme that in humans is encoded by the ERBB2 gene. Over expression of this gene is correlated with higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family." - Wikipedia
Return to Top"International Nonproprietary Name, is the official nonproprietary or generic name given to a pharmaceutical substance, as designated by the World Health Organization (WHO)." - Wikipedia
Return to Top"The mammalian target of rapamycin (mTOR) also known as mechanistic target of rapamycin or FK506 binding protein 12-rapamycin associated protein 1 (FRAP1) is a protein which in humans is encoded by the FRAP1 gene. mTOR is a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcription." - Wikipedia
Return to Top"Necrosis is the premature death of cells and living tissue. Necrosis is caused by factors external to the cell or tissue, such as infection, toxins, or trauma. This is in contrast to apoptosis, which is a naturally occurring cause of cellular death. While apoptosis often provides beneficial effects to the organism, necrosis is almost always detrimental and can be fatal." - Wikipedia
Return to Top"An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease." - Wikipedia
Return to Top"PI3K inhibitor, is a potential medical drug that functions by inhibiting a Phosphoinositide 3 kinase enzyme which is part of the PI3K/AKT/mTOR pathway, which plays a key role in cancer. Inhibiting this pathway often suppresses tumor growth." - Wikipedia
Return to Top"Ribonucleotide reductase (RNR, also known as ribonucleoside diphosphate reductase) is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides. Deoxyribonucleotides in turn are used in the synthesis of DNA. The reaction catalyzed by RNR is strictly conserved in all living organisms. Furthermore RNR plays a critical role in regulating the total rate of DNA synthesis so that DNA to cell mass is maintained at a constant ratio during cell division and DNA repair. A somewhat unusual feature of the RNR enzyme is that it catalyzes a reaction that proceeds via a free radical mechanism of action" - Wikipedia
Return to Top"Somatostatin receptor type 5 is a protein that in humans is encoded by the SSTR5 gene. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins." - Wikipedia
Return to Top"A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases, enzymes responsible for the activation of signal transduction cascades (through phosphorylation of various proteins). TKIs are typically used as anti cancer drugs. They are also called tyrphostins, the short name for tyrosine phosphorylation inhibitor , originally coined in a 1988 publication, which was the first description of compounds inhibiting the catalytic activity of the epidermal growth factor receptor (EGFR)." - Wikipedia
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